Schedule at a Glance

Monday, September 27, 2021
8:00 AM to 4:00 PM
9:00 AM to 4:45 PM
Immunological Memory in Transplantation and Protective Immunity
  • Antibody responses to COVID vaccines in SOT recipients
  • COVID-19 and Hematopoietic Stem Cell Transplantation 
  • COVID-19 and Solid Organ Transplant
  • Current concepts in serological and B cell Memory
  • HLA and COVID19 outcomes
  • Mounting protective anti-viral T cell responses
  • Multiplex IgG for detecting anti-COVID antibodies
  • NK memory
  • Panel Discussion
  • Strategies to activate NK cells to prevent relapse following Hematopoietic Stem Cell Transplantation
  • T cell memory and protection against COVID-19 and other viral infections
  • Tissue Resident memory cells in health, disease and transplantation
  • Trained immunity in organ transplantation
  • Unrecognized Humoral Alloimmune memory in Transplant/Pregnancy
5:00 PM to 6:00 PM
6:00 PM to 7:00 PM
7:00 PM to 9:00 PM
Tuesday, September 28, 2021
7:00 AM to 8:00 AM
8:00 AM to 8:30 AM
8:30 AM to 9:30 AM
9:30 AM to 10:00 AM
10:00 AM to 10:30 AM
10:30 AM to 12:00 PM
Integrated Genomics
  • Structural relationships and information content within the genome, as revealed by complexity theory, and spatial interactions within the MHC
2:15 PM to 3:45 PM
Abstract I: Immunologic Risk Stratisfication
  • CORRELATION OF T- AND B-CELL EPITOPE MISMATCHES WITH DE NOVO DONOR-SPECIFIC ANTIBODY FORMATION IN RENAL TRANSPLANT RECIPIENTS
  • Characterization of permissible HLA allele mismatches from unrelated hematopoietic stem cell transplant cohorts
  • IMPROVED IMMUNOLOGICAL RISK STRATIFICATION OF PEDIATRIC HEART TRASNPLANT PATIENTS BY COMBINING PIRCHE-II WITH HLAMATCHMAKER OR HLA-EMMA.
  • SHARED T-CELL EPITOPES BETWEEN IMMUNIZING AND DONOR HLA ASSOCIATE WITH KIDNEY ALLOGRAFT SURVIVAL
Abstract II: Bench to Bedside Applications
  • HLA CLASS II PARTNERING WITH TLR4 STIMULATES CELL PROLIFERATION, P-SELECTIN EXPRESSION, AND MONOCYTE RECRUITMENT TO ENDOTHELIAL CELLS
  • HMGB1-TLR4 and HMGB1-TLR9 Axes Differentially Polarize Macrophages to Distinct Phenotypes that Contribute to Alloimmunity Following Ischemia-Reperfusion Injury in Human Orthotopic Liver Transplantation
  • The sex chromosome complement influences humoral immunity independently of gonadal sex
  • VISUALIZING HLA HAPLOTYPE DIVERSITY USING ALLUVIAL PLOTS
HLA Data Analysis for Population Genetic and Disease Association Studies
  • Population Genetic and Disease Association Analysis using Public Resources
  • The Allele Frequencies Net Database
  • The Allele Frequencies Net Database
  • The IPD-IMGT/HLA GitHub repository and the HLA|COVID-19 database
3:45 PM to 4:15 PM
4:15 PM to 5:45 PM
Abstract III: Solid Organ/Post
  • An information model to report anti-HLA antibodies
  • Donor-derived HLA class II but not class I T-cell epitope targets associate with the occurrence of T cell-mediated rejection after kidney transplantation.
  • MANAGEMENT OF POST-TRANSPLANT COVID-19+ PATIENTS: A SINGLE CENTER EXPERIENCE
  • The impact of imlifidase on donor-specific antibodies (DSAs) in serum samples from patients diagnosed with antibody-mediated rejection (ABMR)
HLA Typing by NGS
  • The Next Next Generation: High resolution HLA typing on the Oxford Nanopore Technology platform
In the Business of Making Heroes: A Glimpse behind the Curtain of OPO Labs
  • Keeping the Lights On and the Transplants Going: Life in the Lab During COVID-19
  • New Kidney Allocation System and its Impacts on OPO Laboratory Operations, including the balance between virtual and physical crossmatch
  • Staying Relevant and Reliable: How OPO Labs Balance the Latest and Greatest in Science with Tried And True Methods, including NGS typing for SOT
6:00 PM to 7:00 PM
6:00 PM to 8:30 PM
7:00 PM to 9:00 PM
Wednesday, September 29, 2021
6:30 AM to 7:30 AM
8:30 AM to 9:30 AM
9:30 AM to 10:00 AM
10:00 AM to 10:30 AM
10:30 AM to 12:00 PM
The New HLA (Mis)Matching Paradigm
  • HLA-matching in allogeneic transplantation for hematologic malignancies: cord blood breaks the rules
2:15 PM to 3:45 PM
Abstract IV: Immunogenetics
  • A decrease in KIR-HLA gene combinations that involve in NK cell maturation is associated with COVID-19
  • SEQUENCE-LEVEL COMPARISON OF NON-CLASSICAL MHC LOCI IN UNRELATED HEMATOPOIETIC CELL TRANSPLANT (HCT) PAIRS
  • The Complex Role of MICA Residue 129 Dimorphism in Hematopoietic Stem Cell Transplantation
  • Validation of HLA matching performance for 300,000 domestic and international donor/recipient pairs for donor requests facilitated by the US Be The Match donor registry
Breaking Barriers to Patient Engagement in the Presence of Challenges and Disparities in Healthcare
  • Inclusion in Patient Engagement: Systemic racism and barriers that need to be addressed to engage with all patients, caregivers, and donors
  • Patient Engagement: What, Why, and How
  • Patient perspective on patient engagement
The Detection and Clinical Utilization of Chimerism and HLA Loss Relapse
  • Clinical utilization:  The value of detecting Chimerism and HLA loss, the importance of test sensitivity/frequency/subsets, in determining engraftment/relapse/MRD/HLA Loss
  • Current field practice/performance: The current state of affairs of ASHI/CAP PT, challenges and gaps, and the future directions
  • Methods comparison: The difference between detecting Chimerism and HLA Loss, the pros/cons among STR, qPCR, NGS, HLA Markers vs Non-HLA markers
3:45 PM to 4:15 PM
4:15 PM to 5:45 PM
6:00 PM to 7:00 PM
Women in Transplantation Session & Reception
  • Pathways to creating equity and inclusion, change is our collective responsibility
Thursday, September 30, 2021
8:00 AM to 9:30 AM
9:30 AM to 10:00 AM
10:00 AM to 10:30 AM
10:30 AM to 12:00 PM
New Frontiers For Histocompatibility Testing
  • Bioprinting for 3D Perfusable Tissues at Therapeutic Scale
2:15 PM to 3:45 PM
Abstract V: Precision Diagnostics
  • EDITING OF THE HLA GENE: A NOVEL THERAPY FOR AUTOIMMUNITY
  • GENE EDITING OF DRB1*04:01 AT POSITION 71 BLOCKS COLLAGEN SENSITIZATION AND AVOIDS ALLORECOGNITION
  • Machine Learning Approach for Binning Donor-Recipient HLA Amino Acid Position Mismatches to Detect Association with Kidney Graft Failure
  • Precision medicine and epitope-based matching: rapid and precise determination of antibody-defined epitopes at all 11 HLA gene loci by the LABType XRSSO/SSO genotyping method.
Case Studies/International Scholar Presentation
  • HLA-DQ-specific recombinant human monoclonal antibodies allow for in-depth analysis of HLA-DQ epitopes
  • HYPERACUTE REJECTION IN HEART TRANSPLANT DUE TO ABO BLOOD TYPE INCOMPATIBILITY: CASE STUDY AND VALIDATION OF ABO GENOTYPING FOR DECEASED DONOR TESTING
  • Leukemia Relapse with >99% Donor T cells and Newly emerging Recipient Myeloid Cells---Immune Escape?
  • RARE GENETIC ALTERATIONS IN HLA GENES AND THEIR IMPACT ON CLINICAL HLA TYPING
4:00 PM to 5:00 PM
ASHI Diversity and Inclusion Workshop
  • ASHI’s Diverse and Equitable Path into the Future
  • President’s Introduction to Diversity and Inclusion at ASHI
  • Spectra Diversity Survey of the ASHI community
5:00 PM to 6:00 PM
Friday, October 1, 2021
8:00 AM to 9:00 AM
9:00 AM to 9:30 AM
9:30 AM to 10:30 AM
The HLA lab of Tomorrow (land): One-stop shopping for immunological assessments
  • A Fairytale Case Study- Part 1 Pre-transplant Immunological assessments
  • Main Street Molecular HLA Mismatch: putting it into practice
  • STAT- NGS HLA typing: Fantasyland is here!
10:30 AM to 10:45 AM
10:45 AM to 12:00 PM
The HLA lab of Tomorrow (land): One-stop shopping for immunological assessments
  • A Fairytale Case Study- Part 2 Post-transplant Immunological assessments
  • DSA Adventureland: new Non-HLA bead panels
  • Next Frontier(land) Cell-free DNA: identifying the source
  • The Wonderful World of non-invasive transcriptomic signatures